Rbm38 hif1
WebNov 23, 2024 · Objective The study is to research how miR-34-SIRT1 is regulated during hypoxia in lung cancer cells. Results Analysis of publicly available datasets from patients … WebAug 17, 2012 · RBM38 was shown to be necessary for proper p53 function, ... may be resistant to hypoxia not only because of decreased apoptosis and senescence but also because of increased HIF1 signalling, ...
Rbm38 hif1
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Webfactor family are targeted by Rbm38, either through RNA stability or RNA translation. Among these family members, Rbm38 stabilizes mRNAs of p21 and p73, while it destabilizes p63 mRNA [9, 11, 22]. Interestingly, phosphorylation of Rbm38 by glycogen synthase kinase 3 (GSK3) converts Rbm38 from a translational repressor to an activator [24 ... WebThe RNA-binding protein Rbm38, also called RNPC1, is a 7, 8). Rbm38 is found to regulate expression of genes necessary for several cellular processes, including cell growth and differenti-ation. For example, Rbm38 is found to regulate Mdm2, p21, p73, and Pten mRNA stability through binding to the AU/U-rich elements in their 3UTRs ( 8–11).
WebDec 15, 2014 · But too much p53 suppresses cell-cycle progression, causing cell death, premature aging and even cancer." The relationship between p53 and Rbm38 can best be described as a loop: p53 regulates ... WebMar 9, 2024 · RNA binding Motif protein-38 regulates myocardial hypertrophy in LXR-alpha-dependent lipogenesis pathway. [RBM38 Mediates the Proliferation of Acute Myeloid Leukemia Cells HL-60 by Regulating FZD1 mRNA Stability]. RNA-binding protein RBM38 inhibits colorectal cancer progression by partly and competitively binding to PTEN 3'UTR …
WebBioGRID Interaction 2470505 Between RBM38 And HIF1A. Toggle navigation. Bio GRID 4.4 WebFunction of RBM38 in human cancer phenotypes a Under hypoxia of lung cancer cells in vitro, HIFα and RBM38 are induced and the former upregulates SIRT1 to inhibits tumor …
WebDiscovery. The HIF transcriptional complex was discovered in 1995 by Gregg L. Semenza and postdoctoral fellow Guang Wang. In 2016, William Kaelin Jr., Peter J. Ratcliffe and Gregg L. Semenza were presented the Lasker Award for their work in elucidating the role of HIF-1 in oxygen sensing and its role in surviving low oxygen conditions. In 2024, the same three …
WebJan 6, 2015 · PDF Hypoxia-inducible factor 1 (HIF1), a heterodimeric transcription factor, ... Hypoxia-inducible factor 1 alpha is regulated by RBM38, a RNAbinding protein and a p53 … description of monopoly gameWebMar 21, 2024 · RBM38 (RNA Binding Motif Protein 38) is a Protein Coding gene. Diseases associated with RBM38 include Lung Cancer and Erythema Infectiosum . Gene Ontology … chsp contribution amounts for servicesWebJul 8, 2024 · RBM38 is located on chromosome 20q13.31 and is highly expressed in a variety of human tissues (RPKM > 4 in 19 of 27 tissues; Fig. 1).Comparative phylogenic … chsp department of healthWebNov 16, 2014 · HIF1 belongs to a subfamily of the basic-helix-loop-helix-PAS transcription factors . In response to high levels of oxygen, HIF1α protein is modified by prolyl … description of motte and bailey castlesWebThe possibility of targeting and integrating RBM38 and LXR-α as a therapeutic approach against car-diac remodeling has never been investigated. Herein, we provide evidence to support that RBM38 is a potential modulator of myocardial hypertrophy via the LXR-α-Dependent lipogenesis pathway. description of mount mayonWebFrom the oncology field is known that Rbm38 has a role in the stabilization of the cell cycle inhibitor p21. 8, 25 Indeed we found silencing of Rbm38 to significantly inhibit p21 levels which was ... description of mountain viewsWebDownload scientific diagram RBM38 directly binds to HIF1α 5′ and 3′ UTRs. (A) Whole cell lysates from H1299 cells were collected and immunoprecipitated with anti-RBM38 … description of mother daughter relationship