WebDNA synthesis inhibitors are a group of antibiotics that target the synthesis of DNA in bacteria and other organisms. Metronidazole, a 5-nitroimidazole, prevents the synthesis of nucleic acids, which are the building blocks of DNA, and is effective against many bacteria and protozoans. Metronidazole and related 5-nitroimidazoles are relatively ... WebJan 2, 2004 · Hydroxyurea (HU) 1 is a potent inhibitor of the enzyme ribonucleotide reductase (RNR) and inhibits DNA replication in a wide variety of cells, including Saccharomyces cerevisiae ( 1 ). The simplest explanation for HU inhibition of DNA synthesis is that it starves the DNA polymerase at the replication forks for dNTPs.

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WebWe examined the effects of 18 h of incubation of Chinese hamster ovary (CHO K1) cells with cycloheximide, hydroxyurea, and aphidicolin. Treatment of cells with cycloheximide alone at a concentration adequate to inhibit DNA synthesis to <10% of control was significantly less cytotoxic and clastogenic than treatment with hydroxyurea or aphidicolin, did not induce … Webinhibition of DNA synthesis by acting as a ribonucleotide reductase inhibitor, without interfering with the synthesis of ribonucleic acid or of protein. This hypothesis explains … how are agonal rhythm and asystole the same

Effect of hydroxyurea on ribonucleotide reductase - ScienceDirect

WebHydroxyurea is a highly specific, rapidly acting inhibitor of DNA synthesis in HeLa S3 cells. It is without detectable effect on cells that are not synthesizing DNA. Incubation in inhibitory … WebHydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby … WebBiochemical studies have shown that hydroxyurea is an effective in- hibitor of DNA synthesis but has little effect on the synthesis of RNA (YOUNG and HODAS, 1964; YARBO … how are age uk funded