Fsh directly regulates bone mass

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August undefined, 2024

WebOct 1, 2024 · In 2006, we published the first evidence that, by increasing bone resorption by osteoclasts, FSH could itself regulate bone mass in … WebOct 1, 2024 · In 2006, we published the first evidence that, by increasing bone resorption by osteoclasts, FSH could itself regulate bone mass in animal models . More recently, we found that FSH regulates body fat and that blocking FSH action on its receptor, expressed in both bone and fat cells ( 17 , 18 ), not only increases bone mass but also reduces …

Follicle-stimulating hormone does not directly regulate bone mass …

WebMar 3, 2024 · The pathogenesis of osteoporosis in women involves increased bone resorption resulting from changes in estrogen and FSH levels at menopause and decreased bone formation caused by a variety of factors associated with the aging process . In addition to secondary forms of osteoporosis, hematologic malignancy as MM plays a very … WebApr 21, 2006 · Postmenopausal osteoporosis, a global public health problem, has for decades been attributed solely to declining estrogen … tlb timesheet

FSH, Bone Mass, Body Fat, and Biological Aging. - Europe PMC

WebMay 1, 2006 · In 2006, we reported for the first time that FSH also directly regulates bone remodeling. It acts on FSH receptors (FSHRs) coupled to the G protein, G i2α , to … WebThe past decade has shown that pituitary hormones can act directly on the skeleton and other tissues, a paradigm shift that is in stark contrast to previously held views on their sole regulation of endocrine targets (15–25).We and others have shown that FSH can bypass the ovary to act on G i-coupled FSH receptors (FSHRs) on osteoclasts to stimulate bone … WebApr 1, 2006 · Search worldwide, life-sciences literature Search. Advanced Search tlb stream

First-in-class humanized FSH blocking antibody targets bone and fat - PNAS

FSH versus estrogen: Who

WebBone mass is increased and osteoclastic resorption is decreased in haploinsufficient FSHβ +/-mice with normal ovarian function, suggesting that the skeletal action of FSH is … WebMay 3, 2013 · Subsequent studies confirmed that monoclonal or polyclonal antibodies against human FSHβ could attenuate osteoclastogenesis [13] and that FSH injections could increase bone loss in ovariectomized rats [14].Moreover, Sun et al. found that FSH can directly regulate the bone mass independent of estrogen [15]. tlb spanishWebMay 1, 2006 · This happens because FSH directly regulates osteoclasts and bone resorption. These two conclusions represent a major shift in two paradigms : first, FSH, like LH, was thought to target exclusively cells in ... It should also be noted that showing that a decrease in FSH increases (modestly) bone mass does not automatically imply the … tlb timber

"WebSep 7, 2024 · Mechanism of FSH action on bone cells. Protein and mRNA expression of FSHR have been detected in human monocytic cells (sharing the same lineage with … " - Fsh directly regulates bone mass

Fsh directly regulates bone mass

The effect of a high-calorie diet on bone growth is mediated by …

WebJul 1, 2024 · FSH directly regulates bone mass. Cell. 2006; 125 (2): 247-260. Google Scholar. ... Effects of recombinant follicle-stimulating hormone on bone turnover … WebFSH Directly Regulates Bone Mass - the laboratory of endocrinology ... EN English Deutsch Français Español Português Italiano Român Nederlands Latina Dansk Svenska Norsk Magyar Bahasa Indonesia Türkçe Suomi Latvian Lithuanian český русский български العربية Unknown

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WebApr 7, 2010 · Hypothalamic gonadotropin-releasing hormone (GnRH) stimulates secretion of pituitary luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which directly regulate ovarian function. Pituitary FSH can modulate osteoclast development, and thereby influence bone turnover. Pituitary oxytocin and prolactin effects on the skeleton are not … WebFollicle-stimulating hormone does not appear to have a major role in the development of bone loss in young women with primary amenorrhea. Follicle-stimulating hormone does not directly regulate bone mass in human beings: evidence from nature Fertil Steril. 2008 Dec;90(6) :2211-6. doi ... bone turnover markers, bone mass, and patient ...

WebThrough high-affinity receptors, some of which are variants of the ovarian FSH receptor (FSHR), FSH regulates bone mass, adipose tissue function, energy metabolism, and cholesterol production in both sexes. These newly described actions of FSH may indeed be relevant to the pathogenesis of bone loss, dysregulated energy homeostasis, and ... WebThrough high–affinity receptors, some of which are variants of the ovarian FSH receptor (FSHR), FSH regulates bone mass, adipose tissue function, energy metabolism, and cholesterol production in both sexes. ... Of note was that the number of aortic plaques was associated directly with serum FSH levels, but was unrelated to serum estrogen ...

WebBone mass is increased and osteoclastic resorption is decreased in haploinsufficient FSHb +/ mice with normal ovarian function, suggesting that the skeletal action of FSH is … WebBone mass is increased and osteoclastic resorption is decreased in haploinsufficient FSHbeta+/- mice with normal ovarian function, suggesting that the skeletal action of FSH …

WebSep 29, 2024 · Sun L, Peng Y, Sharrow AC, Iqbal J, Zhang Z, Papachristou DJ, et al. FSH directly regulates bone mass. Cell. 2006;125:247–60. Article CAS Google Scholar Legg JA, Herbert JM, Clissold P, Bicknell ... tlb thrashingWebWe have shown previously that the reproductive hormone FSH, the levels of which rise after menopause, regulates both body fat and bone mass. We now show that blocking FSH … tlb to dllWebSep 1, 2010 · The reduced osteoclastic activity in eugonadal FSH haploinsufficient mice demonstrates that FSH regulates bone mass directly, independently of estrogen. An examination of FSHβ –/– and FSHR –/– homozygous knockout mice demonstrated preserved bone mass despite severe hypogonadism [ 1 ]. tlb to cupWebFSH directly regulates bone mass. Cell 125: 247–260. [Google Scholar] Takeda S, Elefteriou F, Levasseur R, Liu X, Zhao L, Parker KL, Armstrong D, Ducy P, Karsenty G. 2002. Leptin regulates bone formation via the sympathetic nervous system. Cell … tlb to hireWebFeb 12, 2024 · This reduced bone mass is also accompanied by increases in visceral adiposity, a disruption of energy metabolism, and decreased physical activity (5, 6). These aberrations have been shown, in clinical studies, to be reversed by pharmacologic doses of estrogen . Our studies have shown that FSH directly affects both bone and fat (8, 9). tlb to idlWebMay 1, 2006 · This happens because FSH directly regulates osteoclasts and bone resorption. These two conclusions represent a major shift in two paradigms : first, FSH , like LH ... knockout mice provide evidence that sex hormones can regulate bone mass independent of FSH: double ER null female mice have a low bone mass (Sims et al., … tlb timbersWebFeb 4, 2009 · Thyrotoxicosis is associated with a high-turnover osteoporosis, which has been solely attributed to elevated thyroid hormone levels. Mice lacking the thyroid hormone receptors α and β establish a role for thyroid hormones in regulating bone remodeling. We show that TSH, which falls when thyroid hormones rise, directly suppresses bone … tlb tinted moisturizer