WebFeb 1, 2024 · FAC-treated ECs had significantly higher levels of Tf and His-FTH1 in the released exosomes compared to DFO-treated ECs (Fig. 4, E and F). Download : Download high-res image (1MB) Download : Download full-size image; Figure 4. BBBECs iron concentration alters the release of exosomes and exosomes containing FTH1 and Tf into … WebApr 9, 2024 · It is a 24-mer complex made up of ferritin heavy chain 1 (FTH1) and ferritin light chain (FTL) subunits that form a hollow nanocage, storing ~4,500 Fe 3+ atoms per complex . Although similar in sequence (55% shared) the two ferritin subunits have different functions and their ratios differ in tissues. ... Additionally, DFO and DFX are effective ...
Iron loss triggers mitophagy through induction of …
WebSep 22, 2024 · FTH1 knockdown promoted cell growth while DFO, vitamin C, 5-FU, JQ1, and doxorubicin treatment reduced it (Fig. 8A–E). Moreover, a minimal increase in cell … WebAddress: 201 Middlesex Center Boulevard 1000 Riverside drive, Suite A Monroe NJ 08831. Phone: (732) 661-1100 (800) 544-3580. Fax: Main Fax: (732) 661-1600 photo of alligator
FTH promotes the proliferation and renders the HCC cells …
WebDec 29, 2024 · The expression level of FTH1 in various tumors. A The expression of FTH1 in various cancer types was summarized by the SangerBox tool.B Heatmap showed the relationship of overall survival and FTH1 in varieties of cancers (GEPIA database).C Transcriptional expression profiles of FTH1 in multiple cancer types (Oncomine … WebMay 9, 2024 · Tetrandrine citrate (TetC), a novel tetrandrine salt with high water solubility, demonstrates a potent antitumor activity in chronic myeloid leukemia. Studies have indicated an important role of ferroptosis in breast cancer (BC). However, whether TetC inhibits BC progression via ferroptosis has never been explored. In the present study, we showed … WebOct 14, 2024 · Ferritin is a pivotal intracellular protein that stores iron, composed of ferritin light chain (FTL) and ferritin heavy chain 1 (FTH1), which protects the cell from free iron participating in the generation of free radicals via Fenton-like reactions (Dixon et al., 2014). Considering USP8 is a deubiquitination enzyme, we tested whether FTL, a ... photo of alligator in swimming pool