Cumulative weighted context++ score
WebAug 15, 2024 · The predicted targets with a cumulative weighted context++ score < -0.4 were merged for the 10 most connected miRNAs in both modules and used as input for DAVID. Figures were obtained using R ... WebApr 15, 2024 · Glycogen synthase 1 (GYS1) was identified in both programs as a target with high score for miR-122 in human (target score 95, miRDB) and bovine (-0.96 cumulative weighted context++ score; TargetScan8.0). Additional predicted targets for miR-122 included forkhead box O3 (FOXO3) and myocyte enhancer factor 2D (MEF2D).
Cumulative weighted context++ score
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WebApr 6, 2024 · Background Despite significant advancements in multiple myeloma (MM) therapy, the highly heterogenous treatment response hinders reliable prognosis and tailored therapeutics. Herein, we have studied the clinical utility of miRNAs in ameliorating patients’ management. Methods miRNA-seq was performed in bone marrow CD138+ plasma cells … WebAug 24, 2024 · Cumulative weighted context++ score：累计加权分值，数字越小，靶点可能性越大； Total context++ score：总评分值，数字越小，靶点可能性越大； …
WebTo calculate the CWCS, for each site i, from 1 to n, the cumulative predicted repression at that site (C i) was calculated as C i = C (i-1) + (1-2 CSi ) (AIR i -C (i-1) ), in which CS i … WebDec 8, 2024 · Next, we searched for miR‐493‐5p targets using public databases. Among the target genes that bind to and are repressed by the miR‐493‐5p sequence, 50 target genes were selected to increase the cumulative weighted context++ score. We also searched TCGA for proteins whose low expression in cholangiocarcinoma was associated with …
WebMay 9, 2024 · The interaction score of not < 0.7 (high confidence score) was considered significant and the PPI was visualized. ... According to the predicted efficacy of targeting … WebThe context++ score (CS) for a specific site is the sum of the contribution of 14 features. A weighted context++ score (WCS; Nam et al., 2014) adds the contribution of the …
WebAug 24, 2024 · Cumulative weighted context++ score：累计加权分值，数字越小，靶点可能性越大； Total context++ score：总评分值，数字越小，靶点可能性越大； …
WebAug 24, 2024 · Cumulative weighted context++ score：累计加权分值，数字越小，靶点可能性越大； Total context++ score：总评分值，数字越小，靶点可能性越大； Aggregate PCT：种间进化保守计算的分值，分值越高，保守性越广； Previous TargetScan publication (s)：报道该靶点预测的参考文献。 三、点击Sites in UTR（结合位点） 以miRNA的靶基 … iowa realty recreational propertiesWebComparing the sum of the predicted site scores in coding sequence (CDS score) against various 3'UTR sizes of targeted (green line) and non-targeted (blue line) genes on an independent test set ... iowa realty urbandale listingsWebBased on a minimal score of 0.4, we identified 31 autophagy-related DEmRNAs that may interact with 14 DEmiRNAs (Figure 4A, Tables 1–3). In total, there were 25 DElncRNAs, … iowa realty townhomes ankeny iowaWebFeb 23, 2024 · Target genes were checked for following parameters: (i) their representative transcripts, (ii) number of 3P-seq tags supporting UTR +5, (iii) link to sites in UTRs, (iv) conserved sites/poorly conserved sites, (v) cumulative weighted context++ score, (vi) total context++ score, and (vii) aggregate PCT (preferentially conserved targeting) values. iowa realty southWebSep 1, 2024 · Cumulative weighted context++ score: This score estimates the total repression expected from multiple sites of the same miRNA, for each mRNA target predicted. 1.1. Cancer stem cells and Wnt pathway. WNT signaling is implicated in various key processes such self-renewal of cancer stem cells and differentiation via several … opendaylight unable to loginWebEvaluation by a variety of measures shows that fitting a sequence-based algorithm into the framework of miRACLe can improve its prediction power with a significant margin, and … open daylight sdn controllerWebNotes: The cumulative weighted context++ scores, which indicate how effectively a given miRNA may target mRNAs, are shown by the node color. The figure was generated … open day newton roma