Cisplatin renal function

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August undefined, 2024

WebMain outcome measure: Cisplatin dose in mg/m(2) based on kidney function and according to the dosing recommendations. Results: Among 1,364 cycles of cisplatin, … WebIn general, any patient with a GFR70 mL/min should be highlighted as ‘at risk’ from cisplatin renal toxicity. Kintzel PE, Dorr RT. Anticancer drug renal toxicity and elimination: dosing guidelines for altered renal function. Cancer Treat Rev. 1995; 21: 33–64GFR (mL/min) Dose60 100%50–60 75%40–50 50%40 AvoidBennett 50 100%10–50 75%

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WebMar 29, 2024 · Nephrotoxicity is characterized by reduced kidney function. Although an often-reversible condition, effects are notably seen years after treatment with cisplatin has ceased. It has an extensive pathophysiological map. The purpose of this article is to consolidate cisplatin-induced acute kidney injury literature and present it in one … WebMar 2, 2024 · To assess the influence of cisplatin on renal function in the short and long terms, we recorded the baseline creatinine level, the maximum creatinine value a few … grand county co library

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WebFeb 16, 2024 · This drug can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and … WebAbstract Cisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney … WebOct 13, 2024 · Cisplatin-induced acute kidney injury (AKI), characterized by rapid loss of renal function within days of initiating treatment, occurs in around 30% of patients who … chinese buffet carling avenue ottawa

Risk factors for renal toxicity after inpatient cisplatin ...

WebDec 2, 2024 · Cisplatin is a commonly used chemotherapeutic drug for cancer treatment, but its nephrotoxicity may lead to the deterioration of renal function. Previous work has been focused on cisplatin-induced acute kidney disease, whereas the mechanism of chronic kidney disease after cisplatin chemotherapy is largely unknown. In the present … WebMar 23, 2024 · Histologic evaluation and blood urea nitrogen (BUN) confirmed that renal structure and function were preserved 48 h after cisplatin injury. Similarly, weight loss was slowed down. grand county boccWebSep 1, 2024 · Cisplatin for injectioncan cause dose-related nephrotoxicity, including acute renal failure that becomes more prolonged and severe with repeated courses … chinese buffet carmichael ca

"WebJun 18, 2024 · The current use of cisplatin in regimens involving pre and posthydration with careful monitoring of diuresis in the treatment of testicular tumors is associated with … " - Cisplatin renal function

Cisplatin renal function

Kidney damage after Cisplatin — Cancer Survivors Network

WebSep 2, 2024 · We detected the therapeutic effects of MLT for renal function during the process of AKI in the CLP mouse model, which is the golden and world-wide accepted mouse model for sepsis. ... Melatonin Attenuates Cisplatin-Induced Acute Kidney Injury through Dual Suppression of Apoptosis and Necroptosis. Biology (Basel). 8, 64. …

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WebWhat Cisplatin Is Used For: Treatment of advanced bladder cancer, metastatic ovarian cancer, and metastatic testicular cancer. Testicular, ovarian, bladder, head and neck, … WebImpaired Renal Function Cisplatin displays high tissue uptake in the kidneys and exhibits dose-related and cumulative nephrotoxicity. It is excreted mainly in the urine. The …

WebMar 12, 2024 · Nephrotoxicity is a known side effect of several treatments, including cisplatin, carboplatin, ifosfamide, radiotherapy and nephrectomy, and can cause glomerular filtration rate (GFR) impairment, proteinuria, tubulopathy, and hypertension. Evidence about the long-term effects of these treatments on renal function remains inconclusive. WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in kidney function, as manifested by a decline in the glomerular filtration rate (GFR), can be dose …

WebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in … WebDec 21, 2024 · Myo-inositol, a carbocyclic sugar, is believed to be relevant to renal pathobiology since the kidney is the major site for its catabolism. Its role in acute kidney injury (AKI) has not been fully investigated. Ferroptosis, a unique form of regulated cell death, is involved in various types of renal injuries. The relevance of myo-inositol with …

WebClearance of cisplatin, etoposide, and ifosfamide depends on kidney function and dosages should be adjusted in patients with renal impairment. However, there is still limited data on the adherence of physicians to dosing recommendations for these drugs in cancer patients with renal impairment. Three …

WebAug 22, 2015 · Cisplatin has a well-established role in the treatment of broad spectrum of malignancies; however its use is limited because of cisplatin-induced nephrotoxicity (CIN) which can be progressive in more than 50% of cases. grand county colorado boccWebJan 11, 2024 · During and after cisplatin treatment. Renal function should be closely monitored before each dose of chemotherapy every 1–2 weeks. chinese buffet carrboro ncWebSep 1, 2024 · Cisplatin induces multiple intracellular injury pathways, including inflammation, oxidative stress, apoptotic pathways, and DNA damage mediating renal tubular cell injury. chinese buffet bury the rockhttp://www.bccancer.bc.ca/drug-database-site/Drug%20Index/Cisplatin_monograph.pdf grand county colorado collectorWebMar 13, 2024 · Background. Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the … grand county colorado building deptWebCisplatin can enter the renal tubular cells by either passive diffusion or active transport. Previous studies have indicated that movement of cisplatin through the renal tubular … grand county colorado clerk and recorderWebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic … chinese buffet carson and hawthorne blvd